Gastroretentive Tablets

The present study was undertaken with an aim formulation and evaluation of Bilayer Tablets containing Candesartan and Simvastatin by Direct compression and wet granulation method to formulate a stable, safe and convenience dosage form for the better management of most common cardiovascular disorders blood pressure. The formulations of Bilayer tablets showed good results in case of Candesartan immediate release layer physicochemical parameters and prepared using concentration of super disintegrant sodium starch glycolate for the fast release layer and sustained release layer of simvastatin containing HPMC K100 M and ethyl cellulose for the delay the drug release up to 10-12 hrs. The FTIR analysis indicates that the drug is pure. Pre compression and post compression parameters were found to be within the satisfactory limits and hence suitable to formulate Bilayer tablets. The data obtained from in vitro release study shows that there is a delay in release of drug simvastatin from the sustained layer that is just because of its hydrophobic characteristics of the polymer ethyl cellulose and the mechanism involved in the release of drug is due to erosion of polymer surface from the matrix.

The development of targeted medication delivery systems has created new ways to improve treatment outcomes, especially with the help of nanotechnology. The goal of this work was to create and describe pH-sensitive nanoparticles that would improve drug delivery by releasing the drug more in the intestines or other physiological settings and less in the stomach. We made nanoparticles in a lab by changing the ratio of polymer to drug using Eudragit® S100, PLGA, and chitosan. Characterization showed that larger polymer concentrations made the particles bigger (145–203 nm) and gave them more negative zeta potentials, which meant they were more stable. The efficiency of drug entrapment ranged from 61% to 84%, and it got better as the amount of polymer rose. SEM analysis indicated that the particles were spherical and evenly spread out. In vitro release assays showed that the drug's release depended on pH, with the least release at pH 1.2 and the most release between pH 6.8 and 7.4. ANOVA and Tukey HSD statistical tests showed that these results were strong. In general, the work shows that pH-sensitive nanoparticles could be good carriers for targeted oral medication administration.