and Bioavailability.

The present study was undertaken with an aim formulation and evaluation of Bilayer Tablets containing Candesartan and Simvastatin by Direct compression and wet granulation method to formulate a stable, safe and convenience dosage form for the better management of most common cardiovascular disorders blood pressure. The formulations of Bilayer tablets showed good results in case of Candesartan immediate release layer physicochemical parameters and prepared using concentration of super disintegrant sodium starch glycolate for the fast release layer and sustained release layer of simvastatin containing HPMC K100 M and ethyl cellulose for the delay the drug release up to 10-12 hrs. The FTIR analysis indicates that the drug is pure. Pre compression and post compression parameters were found to be within the satisfactory limits and hence suitable to formulate Bilayer tablets. The data obtained from in vitro release study shows that there is a delay in release of drug simvastatin from the sustained layer that is just because of its hydrophobic characteristics of the polymer ethyl cellulose and the mechanism involved in the release of drug is due to erosion of polymer surface from the matrix.