Withania Somnifera

The aim of the current research is to prepare and test sustained-release (SR) tablets of Metformin hydrochloride using hydrophilic polymers such as Hydroxypropyl Methylcellulose (HPMC), Xanthan gum and Eudragit RSPO so as to attain sustained glycemic control in diabetic animal models. The wet granulation method is used to prepare tablets and the physicochemical properties such as weight variation, hardness, friability, thickness and uniformity of drug content are determined and all are found to be within acceptable limits. In vitro drug release showed a release of Metformin is controlled over 12 hours with release kinetics consistent with the Korsmeyer-Peppas model, reflecting diffusion and erosion. Sustained drug absorption is observed in streptozotocin-induced diabetic Wistar rats in which in vivo pharmacokinetic analysis of the SR formulations demonstrated a long Tmax and half-life (t1/2) and higher area under the plasma concentration-time curve (AUC) than immediate-release Metformin. One-way ANOVA and Tukey post-hoc statistical analysis showed that there are significant differences between formulations (p

Ineffective aqueous solubility is one of the major issues in oral drug delivery which usually provides poor therapeutic efficacy of Biopharmaceutics Classification System (BCS) Class II drugs. The paper contains a straightforward experimental search based on the comparison of two known formulation approaches, solid dispersion ( SD) and nanosuspension, (NS ), to improve the dissolution of a model, poorly soluble drug. SD was made through evaporation of solvents whereas NS was formulated at a high pressure of homogenization. Particle size analysis, scanning electron microscopy (SEM), differential scanning calorimetry (DSC), powder X-ray diffraction (PXRD) and dissolution test were used to characterize the formulations. The outcomes were that NS attained a remarkably lower particle size (210.4 ± 5.8 nm) than SD (4.85 ±- 0.22 mum) which led to increased surface area and increased rate of dissolution. Near-complete amorphization in NS (12.8 % crystallinity) as compared to partial amorphization in SD (42.5 %). In dissolution studies, 96.2 percent of drug released after 30 minute (NS) compared to SD (85.4 percent) and pure drug (34.6 percent). Both of these formulations- were stable under accelerated conditions. The results show that both the methods can bring a tremendous difference to the amount of dissolution but the nanosuspension method is more effective than the solid dispersion method and can be used where fast acting drug is required but the solid dispersion method can help where formulation based on stability is important to the solid dosage forms.