Dhanush Ram Turkane

The present research is devoted to the growth and testing of enteric-coated gymnema-sylvestre and Curcuma-longa tablets to be used in the treatment of the small intestines. The preparation of tablets is carried out through a wet granulation method and is coated with Eudragit L100 to avoid the degradation of the active phytoconstituents in the gastric tract. In vitro dissolution experiments show that there is low drug release in acidic gastric (1.2 pH) and release that is site specific and sustained in intestinal pH (6.8), as per ex vivo permeation experiments using rat intestinal segments, which indicate controlled and gradual absorption. Comparative study indicates that coated tablets have better gastric stability, delayed intestinal release and higher permeation efficiency as opposed to uncoated tablets. The statistical analysis of the data shows that the release and intestinal permeation differences between drugs are significant (p

Animal-based testing is important for understanding the performance, mechanism, and translational capacities of floating tablets and in-vitro testing for stomach retention, which is the focus of the current review.  With a limited window for absorption in the upper gastrointestinal tract, drug delivery systems (FDDS) are designed to improve the residence time, bioavailability, and controlled release of medications.  The recipes that employed gas-producing agents like sodium bicarbonate and citric acid, as well as hydrophilic polymers like HPMC, carbopol, and sodium alginate, demonstrated exceptional floating properties with a lag time of less than 12 hours. In vitro research studies showed sustained release profiles along the zero-order or non-Fickian kinetics, whereas in vivo testing in albino rats and rabbits showed long gastric retention and better pharmacokinetic results. Gastric safety and biocompatibility was confirmed by histopathological assessments. Direct compression was determined to have the best formulation through comparative analysis based on stable and efficient formulations compared to wet granulation. All in all, animal tests will be a critical preclinical base to determine optimal proportions of polymers, buoyancy, and release characteristics which will make floating pills safe and effective when applied to the clinical setting.