Enhancing Oral Bioavailability of Poorly Water-Soluble Drugs: Current Developments in Nanotechnology, Lipid Systems, and Solid Dispersions

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References

1. [1]Investigate hybrid delivery strategies that incorporate nanotechnology, lipid-based carriers, and solid dispersions. Make use of machine learning and artificial intelligence to optimise formulations and forecast drug performance. Zhang, X., Xing, H., Zhao, Y., & Ma, Z. (2018). Pharmaceutical dispersion techniques for dissolution and bioavailability enhancement of poorly water-soluble drugs. Pharmaceutics, 10(3), 74. Kumari, L., Choudhari, Y., Patel, P., Gupta, G. D., Singh, D., Rosenholm, J. M., ... & Kurmi, B. D. (2023). Advancement in solubilization approaches: a step towards bioavailability enhancement of poorly soluble drugs. Life, 13(5), 1099. Bhalani, D. V., Nutan, B., Kumar, A., & Singh Chandel, A. K. (2022). Bioavailability enhancement techniques for poorly aqueous soluble drugs and therapeutics. Biomedicines, 10(9), 2055. Kazi, M. (2017). Lipid-Based Nano-Delivery for Oral Administration of Poorly Water Soluble Drugs (PWSDs): Design. Adv. Technol. Deliv. Ther, 3, 31. Bakrey, H., Abdu, A., Shivgotra, R., Soni, B., Sharma, M., Bakrey, A., & Jain, S. K. (2025). Innovative strategies and advances in drug delivery systems to address poor solubility: a comprehensive review. Current Drug Targets. Hosszú, Z., Pártos, P., Mahdavi, M., Ujhelyi, Z., Fehér, P., Haimhoffer, Á., ... & Pető, Á. (2026). The Role and Potential of Nanotechnology in Improving Solubility and Enhancing Bioavailability. Pharmaceutics, 18(4), 478. Bhalani, D. V., Nutan, B., Kumar, A., & Singh Chandel, A. K. (2022). Bioavailability enhancement techniques for poorly aqueous soluble drugs and therapeutics. Biomedicines. 2022; 10: 2055. Tran, T. T., & Tran, P. H. (2020). Insoluble polymers in solid dispersions for improving bioavailability of poorly water-soluble drugs. Polymers, 12(8), 1679. Tran, P., Pyo, Y. C., Kim, D. H., Lee, S. E., Kim, J. K., & Park, J. S. (2019). Overview of the manufacturing methods of solid dispersion technology for improving the solubility of poorly water-soluble drugs and application to anticancer drugs. Pharmaceutics, 11(3), 132. Chandramohan, K., Nepolean, R., Karthikeyan, K., Anbarasu, D., & Jayaram, N. (2026). Strategies for Improving Solubility and Dissolution of Poorly Water-Soluble Drugs: Current Developments and Pharmaceutical Applications. Dahma, Z., Álvarez-Álvarez, C., & de la Torre-Iglesias, P. M. (2025). A mini-review on enhancing solubility in topical hydrogel formulations using solid dispersion technology for poorly water-soluble drugs. Colloids and Interfaces, 9(2), 17. Jagtap, M. (2025). Recent Trends in Solubility Enhancement Techniques for Poorly Water-Soluble Drugs. International Journal of Scientific Research and Technology. Parmar, K., & Patel, R. (2025). Novel nano-technologies to enhance drug solubility, dissolution and bioavailability of poorly water-soluble drugs. Biomaterials Connect, 2(1), 1-10.

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