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📢 Latest Update: New special issue call for papers on "Pharmaceutical Research and Integrated Medical Sciences" - Submit by March 31, 2026

📢 Latest Update: New special issue call for papers on "Pharmaceutical Research and Integrated Medical Sciences" - Submit by March 31, 2026

Volume 3, Issue 3 - 2026 (JPRIMS, Vol-3, Issue-03, March.-2026)

Volume 3 Issue 3 Cover

Issue Details:

Volume 3 Issue 3
Published:Invalid Date

Editorial: JPRIMS, Vol-3, Issue-03, March.-2026

Welcome to the 2026 issue of Journal of Pharmaceutical Research and Integrated Medical Sciences. This issue showcases the remarkable breadth and depth of contemporary research across multiple disciplines. From cutting-edge applications of machine learning in climate science to the revolutionary potential of quantum computing in drug discovery, our featured articles demonstrate the power of interdisciplinary collaboration in addressing global challenges.

We are particularly excited to present research that bridges traditional academic boundaries, reflecting our journal's commitment to fostering innovation through cross-disciplinary dialogue. The integration of artificial intelligence with environmental science, the application of blockchain technology to supply chain management, and the convergence of urban planning with smart city technologies exemplify the transformative potential of collaborative research.

As we continue to navigate an era of rapid technological advancement and global challenges, the research presented in this issue offers both insights and solutions that will shape our future. We thank our authors, reviewers, and editorial board members for their continued dedication to advancing knowledge and promoting scientific excellence.

Dr. Arpan Kumar Tripathi
Editor-in-Chief
Journal of Pharmaceutical Research and Integrated Medical Sciences

Articles in This Issue

Showing 8 of 8 articles
Research PaperID: jprims-00000224

Smart Polymers in Pharmaceutical Sciences: Stimuli-Responsive Systems for Targeted Drug Release

Perli. Kranti Kumar Kumar, Saravanan Jaganathan Jaganathan, M. Eswaramoorthi Eswaramoorthi, Saravanan J J, Venkatesan M M

Smart polymers—also known as stimuli-responsive polymers—represent one of the most revolutionary materials in modern pharmaceutics. These polymers can sense environmental triggers such as pH, temperature, enzymes, redox potential, or magnetic fields, and alter their physical or chemical behavior in response. This responsiveness allows the controlled and targeted release of drugs precisely where and when they are needed, maximizing therapeutic efficacy and minimizing systemic side effects. This review explores the classification, mechanisms, formulation approaches, biomedical applications, and regulatory considerations of smart polymer-based drug delivery systems. The discussion emphasizes advances in cancer therapy, diabetes management, and tissue engineering, along with the challenges of large-scale manufacturing and clinical translation.

Gastroprotectivenatural gumManilkara zapota leaf extractsustained release
13,080 views
3,893 downloads
DOI:
10.64063/3049-1681.vol.3.issue3.1

Contributors:

 Perli. Kranti Kumar Kumar
,
 Saravanan Jaganathan Jaganathan
,
 M. Eswaramoorthi Eswaramoorthi
,
 Saravanan J J
,
 Venkatesan M M
Research PaperID: jprims-00000225

Artificial Intelligence in Pharmacology and Pharmaceutics: From Drug Discovery to Clinical Translation

Amrut Arun Swami Swami, S. Shruti Shruti, Perbhat Kansal Kansal, Gayathridevi S S, Anand Bhide Bhide

Artificial intelligence (AI) has emerged as a transformative tool in pharmacology and pharmaceutics, enabling accelerated drug discovery, formulation optimization, and clinical translation. Machine learning, deep learning, and predictive modeling improve target identification, lead optimization, and personalized therapy. AI-driven platforms facilitate high-throughput screening, pharmacokinetic/pharmacodynamic (PK/PD) modeling, and nanocarrier design, reducing time, cost, and attrition rates. This review highlights the applications of AI across the drug development pipeline, from molecular discovery to regulatory submission, and discusses challenges, ethical considerations, and future perspectives in precision pharmacotherapy.

Biopolymers.NanomedicineControlled ReleaseTargeted Drug DeliveryStimuli-Responsive SystemsSmart Polymers
13,174 views
3,960 downloads
DOI:
10.64063/3049-1681.vol.3.issue3.2

Contributors:

 Amrut Arun Swami Swami
,
 S. Shruti Shruti
,
 Perbhat Kansal Kansal
,
 Gayathridevi S S
,
 Anand Bhide Bhide
Research PaperID: jprims-00000226

Biopharmaceutics Meets Neuropharmacology: Advanced Systems for Brain-Targeted Drug Delivery

Neha Mandle Mandle, Devendra Kumar Sahu Sahu, Tarun Kumar Jain Jain, Harsh Kumar Tamrakar Tamrakar, Chiranjeev Sahu Sahu

Brain-targeted drug delivery represents one of the most challenging frontiers in pharmacology due to the presence of the blood–brain barrier (BBB), enzymatic degradation, and efflux transporters. Integration of biopharmaceutics with neuropharmacology has enabled the design of advanced delivery systems that enhance drug bioavailability, specificity, and therapeutic efficacy in central nervous system (CNS) disorders. This review explores current strategies for brain-targeted delivery, including nanoparticles, liposomes, polymeric carriers, and ligand-mediated systems. Mechanistic insights into BBB penetration, pharmacokinetic considerations, and clinical translation challenges are discussed. Future directions involve stimuli-responsive carriers, nanotheranostics, and precision neuropharmacology for personalized CNS therapy.

Clinical TranslationNanomedicinePK/PD ModelingDrug DiscoveryPharmaceuticsPharmacology+1 more
13,473 views
4,035 downloads
DOI:
10.64063/3049-1681.vol.3.issue3.3

Contributors:

 Neha Mandle Mandle
,
 Devendra Kumar Sahu Sahu
,
 Tarun Kumar Jain Jain
,
 Harsh Kumar Tamrakar Tamrakar
,
 Chiranjeev Sahu Sahu
Research PaperID: jprims-00000227

Neuropharmacology of Novel Antipsychotics: Mechanisms, Efficacy, and Future Directions

Devendra Kumar Sahu Sahu, Neha Mandle Mandle, Gautam Dansena Dansena, Harsh Kumar Tamrakar Tamrakar, Deleshwar Kumar Kumar

D₂ antagonism toward multimodal receptor targeting, glutamatergic modulation, and neuroinflammatory regulation. Despite the success of atypical antipsychotics, limitations such as metabolic side effects, cognitive deficits, and treatment resistance persist. Novel compounds—including third-generation antipsychotics, trace amine-associated receptor 1 (TAAR1) agonists, serotonin–dopamine activity modulators (SDAMs), and glutamatergic agents—are redefining psychopharmacology through receptor-biased signaling, synaptic plasticity enhancement, and neuroimmune modulation. This review consolidates current insights into the neuropharmacological mechanisms of emerging antipsychotics, compares their efficacy and safety profiles, and explores future directions in precision psychiatry, AI-based drug design, and neurocircuit-level therapeutics.

ligand-mediated targeting.CNS disordersbiopharmaceuticsneuropharmacologynanoparticlesblood–brain barrier+1 more
13,600 views
4,056 downloads
DOI:
10.64063/3049-1681.vol.3.issue3.4

Contributors:

 Devendra Kumar Sahu Sahu
,
 Neha Mandle Mandle
,
 Gautam Dansena Dansena
,
 Harsh Kumar Tamrakar Tamrakar
,
 Deleshwar Kumar Kumar
Research PaperID: jprims-00000228

3D Printing in Pharmaceuticals: From Personalized Dosage Forms to Regulatory Challenges

Stuti Verma Verma, Yash Srivastav Srivastav, Anup Kumar Sirbaiya Sirbaiya

Three-dimensional (3D) printing has become a transformative technology in pharmaceutical sciences, allowing the creation of customized drug delivery systems with precise control over shape, dosage, and release profiles. This review offers a thorough overview of 3D printing methods used in pharmaceuticals, including their materials, design strategies, characterization techniques, and current clinical and regulatory environments. Applications encompass personalized medicine, polypills, controlled-release implants, and new pediatric formulations. Despite its significant potential, 3D printing faces challenges related to scalability, quality control, and regulatory approval. Recent FDA approvals, notably of the first 3D-printed drug Spritam®, represent important milestones. Future advancements depend on unified guidelines, digital manufacturing integration, and AI-driven formulation improvements.

Neuropharmacology.Precision PsychiatrySchizophreniaReceptor BiasNeuroinflammationTAAR1+4 more
13,500 views
4,024 downloads
DOI:
10.64063/3049-1681.vol.3.issue3.5

Contributors:

 Stuti Verma Verma
,
 Yash Srivastav Srivastav
,
 Anup Kumar Sirbaiya Sirbaiya
Research PaperID: jprims-00000229

Post-Surgical Complications in Shoulder Joint Repair: An Integrative Systematic Review

Sami Suliman Almureef Almureef, Abdullah Almutairi Almutairi

This integrative systematic review investigates the frequency, nature, and risk factors of complications following shoulder joint repair, encompassing arthroscopic rotator cuff surgery, labral stabilization, and arthroplasty. Synthesizing evidence from the last decade, findings indicate that while these procedures are generally successful, surgical complications occur in approximately 5% to 10% of primary cases, rising significantly in revision settings. Arthrofibrosis (stiffness) and persistent pain emerge as the most prevalent issues across all techniques, whereas periprosthetic infection (notably Cutibacterium acnes) and implant loosening are critical concerns in arthroplasty. Medical and anesthetic complications, such as venous thromboembolism and nerve-related events, remain relatively rare but are strongly influenced by patient-specific factors like advanced age, smoking, and diabetes. The review concludes that preoperative optimization and a high index of suspicion for low-grade infections are essential for improving long-term patient satisfaction and surgical longevity.

Fused Deposition ModelingSpritam®Regulatory ChallengesPharmaceutical FormulationPersonalized MedicineAdditive Manufacturing+1 more
13,809 views
4,210 downloads
DOI:
10.64063/3049-1681.vol.3.issue3.6

Contributors:

 Sami Suliman Almureef Almureef
,
 Abdullah Almutairi Almutairi
Research PaperID: jprims-00000231

Design And Evaluation of Nifedipine-Loaded Liposomal Nanocarriers for Enhanced Drug Delivery and Sustained Antihypertensive Therapy: A Systematic Review and Meta-Analysis

R.E. Ugandar Ugandar, S. Subramanyam Rao, A. Venkata Badarinath Badarinath, Pabbati Obaiah Obaiah

Hypertension is a major cause of morbidity and mortality worldwide and requires the development of better drug delivery methods to help maintain long-term drug control. Nifedipine is designed as a dihydropyridine calcium channel blocker but is hampered by inadequate aqueous solubility, thorough first pass metabolism, and short biological half-life. Liposomal nanocarriers, especially elastic and deformable vesicles, have been discovered as potential systems to overcome the limitations. This systematic review and meta-analysis assess the efficacy of liposome formulations in improving the delivery of nifedipine, specifically entrapment efficiency, nifedipine permeation, release kinetics and therapeutic outcomes. Statistic and systematic search of "sur varieties and performance" Eligible studies were identified by systematic search of the literature in PubMed, Scopus and Web of science since 2015-2025. Quantitative synthesis was shown to provide much greater entrapment efficiency (+18.6%), peak permeation rates (standardized mean difference: 1.42) and drug release profiles over time than conventional formulations. Elastic liposomes always outperformed regular liposomes in terms of transdermal delivery and stability. The results confirm that liposomal nanocarriers are substantially able to improve the bioavailability and therapeutic performance of nifedipine, and also provide support for the potential of nifedipine as an antihypertensive drug in an advancement treatment.

Pain ManagementPharmacokineticsNF-Κb PathwayCentral SensitizationHerbal AnalgesicsNociplastic Pain+2 more
13,695 views
4,239 downloads
DOI:
10.64063/3049-1681.vol.3.issue3.7

Contributors:

 R.E. Ugandar Ugandar
,
 S. Subramanyam Rao
,
 A. Venkata Badarinath Badarinath
,
 Pabbati Obaiah Obaiah
Research PaperID: jprims-00000233

Advances in Self-Emulsifying Drug Delivery Systems: Supersaturated, Solid, Hybrid, 3D Printed and Computationally Optimized Approaches

Pabbati Obaiah Obaiah, R.E. Ugandar Ugandar, A. Venkata Badarinath Badarinath, S. Subramanyam Rao Rao

Recent developments, including supersaturation SED Interprovincial Developmental Special Education Council (Su-SEDDS), solid SEDS (S-SEDDS), hybrid systems, 3D printing technologies, and computational modelling, have greatly improved their performance. Su-SEDDS enhance the rate of drug absorption by exerting supersaturation, and S-SEDDS improve stability and patient compliance. Hybrid systems and 3D Printing for targeted and Personalized Drug Delivery. Computational modelling is further used to optimise formulation design and to help predict in vivo behaviour. In the present review, all these innovations and their impact on today's drug delivery are fully discussed.

RP-HPLC Method development Method validation Eltrombopag olamine Pharmaceutical analysis ICH guidelines Chromatography
14,099 views
4,236 downloads
DOI:
10.64063/3049-1681.vol.3.issue3.8

Contributors:

 Pabbati Obaiah Obaiah
,
 R.E. Ugandar Ugandar
,
 A. Venkata Badarinath Badarinath
,
 S. Subramanyam Rao Rao

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