Solid dispersion

Ibuprofen is tough to dissolve in water and possess a limited bioavailability. To enhance dissolution, and stability, the study explores co-solvency-based solid dispersion method involving the application of tamarind seed mucilage as a natural polymer carrier. Drug:mucilage ratios of 1:0.5, 1:1, and 1:1.5, employing ethanol as a co-solvent under a solvent evaporation method. Equivalent physical mixtures were prepared for comparison. Along with FTIR and XRD studies endorsing ibuprofen's change to amorphous nature without chemical interaction with carrier, phytochemical tests established the presence of bioactive chemicals in the mucilage. Substantial progress was demonstrated in in vitro dissolving testing; the SD (3) 1:1.5 formulation had a dissolve efficiency of 91.6% and 99.8% drug release within 60 minutes. Particle size and zeta potential measurements indicated stable surface charges and nanoscale particles, particularly for SD (3). Compared to physical blends and pure ibuprofen, solid dispersions showed improved drug content and release effectiveness throughout the semiannual stability test under 40°C, 75% relative humidity. These results illustrate how tamarind seed mucilage can be utilized in co-solvency-based solid dispersions as an effective and environmentally friendly means of increasing solubility and therapeutic effectiveness of drugs with low aqueous solubility. This approach paves the way for improved drug delivery systems through offering a sustainable, scalable alternative and encouraging more research into natural carriers for drug formulations.

The degraded relationships between the environment and man created via the emergence of environmental issues on drug formulations have stimulated the endeavors to find environmentally friendly and sustainable synthesis procedure of nanoparticle synthesis via green processes. This paper examines the fabrication, properties and the drug application of silver (AgNPs) and gold nanoparticles (AuNPs) that are developed under the influence of medicinal plant extracts as reducing and stabilizing agents. UVVis spectrophotometry, FTIR, XRD, SEM/TEM and DLS analyses were used to synthesise, purify and characterise nanoparticles in complete experimental research study design. It was found that there were individual plasmon resonance peaks of AgNPs (430535 nm) and AuNPs (540545nm), and that AuNPs with smaller sizes (28.731.2 nm), high uniformity, and good colloidal stability as compared to AgNPs. Cell viability in in vitro cytotoxicity assays of all formulations was above 84 % which is excellent biocompatibility. It was found that particle size and zeta potential of the AgNPs and AuNPs significantly differed (ANOVA), whereas cytotoxicity did not. The observed results show that green synthesis is an alternative, sustainable way of producing nanoparticles and that the method could hold value in delivering pharmaceutical drugs and reduce the environmental impact of nanoparticle synthesis.