Brijesh Kumar Pal

VEXAS syndrome (Vacuoles, E1 enzyme, X-linked, Autoinflammatory, Somatic syndrome) is a more recently described, acquired somatic mutation in the UBA1 gene, and is an autoinflammatory disorder of adults. Its clinical features include systemic inflammation, clonal hematopoiesis, abnormalities of the bone marrow and various hematological, rheumatological and dermatologic changes. This review discusses the molecular pathogenesis of VEXAS syndrome with emphasis on the UBA1 mutations, immune dysfunction and disease pathogenesis. In addition, it emphasizes the importance of artificial intelligence, next generation sequencing (NGS), integration of multi-omics and three-dimensional (3D) genomic fingerprinting in the improvement of diagnosis and molecular characterization. The current therapeutic options such as the use of corticosteroids, JAK inhibitors, azacitidine and biologic agents, as well as novel stem cell-based therapies are reviewed. Special focus is on the most promising potentially curative therapy, namely, allogeneic hematopoietic stem cell transplantation (HSCT). Although genomic medicine and precision diagnostics has come a long way, there are still issues to be addressed, particularly with respect to diagnosis at an early stage and longer-term management. The synergy of genomics, artificial intelligence (AI), and regenerative medicine could have a profound impact on the care of VEXAS syndrome patients in the future.

Infertility is becoming an increasingly common reproductive health condition globally, leading to a dramatic increase in the use of assisted reproductive technologies, including intracytoplasmic sperm injection (ICSI) and in vitro fertilisation (IVF). Numerous factors, such as the mother, the embryo, and the IVF procedure, contribute to the success rate of in vitro fertilisation (IVF) and live births. Investigated here are in vitro fertilisation (IVF) success rates as a function of oocyte quality, maternal body mass index (BMI), embryo transfer methods, and ICSI. Female infertility patients undergoing in vitro fertilisation procedures at assisted reproduction centres were the subjects of the study, which used a quantitative methodology. Embryonic factors were considered alongside age, BMI, oocyte shape, fertilisation, embryo growth, embryo implantation rate, and pregnancy success rates. A chi-square test, descriptive statistics, regression models, and correlation analyses were all used to analyse the data statistically. The results show that the mother's oocyte quality and body mass index (BMI) significantly affect live birth rates, embryo growth, embryo implantation rate, and fertilisation success. There was a correlation between poor oocyte quality and high maternal BMI, lower rates of IVF success, and lower chances of live births.

Infectious leucorrhoea is one of the most prevalent diseases of gynecologic nature involving infection of the reproductive system by fungi, bacteria, and parasites. Recurrent vaginal infections may lead to microbial cross-infections between male sex partners, adversely affecting sexual relations and intimate connections in the couple. This paper attempted to examine the problem of cross-infection, the state of urogenital health of men involved in the research, and the effect of infectious leucorrhoea on sexual arousal in both parties. A cross-sectional observational clinical study was carried out among 80 couples undergoing gynecology and urology clinics visits due to complaints of infectious vaginal discharge. Clinical evaluation, microbial investigation, laboratory tests, and questionnaire were used in the process of information collection. The results have shown that C. albicans was the most common pathogen among women in the sample group. Dysuria, balanitis, and penile irritation were found among men involved in the research, suggesting possible cross-infection from women. Sexual desire loss and avoidance behavior were noticed as well. Analysis of statistics indicates that there were highly significant relationships between infections with leucorrhoea, urogenital problems among men, and compromised sexual wellbeing (p