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Journal of Pharmaceutical Research and Integrated Medical Sciences

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Large Language Models (LLMs) in Hypnosis, Leveraging Machine Learning to Map and Induce Hypnotic Trance States via Real-Time EEG, DORAs, VRH, HRV: Human-Led Hypnosis vs Algorithmically Hypnotherapy for Pain Management

Published in JPRIMS, Vol-3, Issue-06, June-2026 (Vol. 3, Issue 6, 2026)

Large Language Models (LLMs) in Hypnosis, Leveraging Machine Learning to Map and Induce Hypnotic Trance States via Real-Time EEG, DORAs, VRH, HRV: Human-Led Hypnosis vs Algorithmically Hypnotherapy for Pain Management - Issue cover

Abstract

The investigation assessed the potential applications of LLMs, EEG neurofeedback, HRV analysis, DORAS systems, and VRH in the development of AI-powered hypnotherapy solutions for pain therapy. The results proved that AI-based hypnotherapy platforms had higher levels of customization, ability to monitor the states of trance, maintain consistency of sessions, and promote physiological adaptations compared to conventional hypnotherapy approaches based on human hypnotherapists. The quantitative analysis revealed that hypnotherapy sessions assisted by VRH delivered the most effective pain relief outcomes, whereas the EEG and HRV assessments revealed enhanced levels of autonomic relaxation and emotional control in the context of hypnotherapy. The researchers found that despite obvious strengths in terms of scalability, incorporation of neurofeedback, and responsiveness to individual conditions of patients, AI systems lack some qualities inherent to humans such as emotional empathy and rapport building. Overall, it can be concluded that future hypnotherapy systems are more likely to become hybrid human-AI solutions.

Authors (7)

Yash Srivastav Srivastav

D.K.R.R Pharmacy College, Ambe...

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Raman Srivastava Srivastava

KP Singh Memorial Institute of...

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Stuti Verma Verma

Aryakul College of Pharmacy an...

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Anup Kumar Sirbaiya Sirbaiya

KP Singh Memorial Institute of...

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Shivani Singh Singh

D.K.R.R Pharmacy College, Ambe...

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Kamini Prajapati Prajapati

D.K.R.R Pharmacy College, Ambe...

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Vasu Tiwari Tiwari

KP Singh Memorial Institute of...

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jprims-00000267

jprims-01-000267

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How to Cite

Srivastav, Y. & Srivastava, R. & Verma, S. & Anup Kumar Sirbaiya Sirbaiya & Singh, S. & Prajapati, K. & Tiwari, V. (2026). Large Language Models (LLMs) in Hypnosis, Leveraging Machine Learning to Map and Induce Hypnotic Trance States via Real-Time EEG, DORAs, VRH, HRV: Human-Led Hypnosis vs Algorithmically Hypnotherapy for Pain Management. Journal of Pharmaceutical Research and Integrated Medical Sciences, 3(6), xx-xx. DOI:https://doi.org/10.64063/3049-1681.vol.3.issue6.2

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