The investigation assessed the potential applications of LLMs, EEG neurofeedback, HRV analysis, DORAS systems, and VRH in the development of AI-powered hypnotherapy solutions for pain therapy. The results proved that AI-based hypnotherapy platforms had higher levels of customization, ability to monitor the states of trance, maintain consistency of sessions, and promote physiological adaptations compared to conventional hypnotherapy approaches based on human hypnotherapists. The quantitative analysis revealed that hypnotherapy sessions assisted by VRH delivered the most effective pain relief outcomes, whereas the EEG and HRV assessments revealed enhanced levels of autonomic relaxation and emotional control in the context of hypnotherapy. The researchers found that despite obvious strengths in terms of scalability, incorporation of neurofeedback, and responsiveness to individual conditions of patients, AI systems lack some qualities inherent to humans such as emotional empathy and rapport building. Overall, it can be concluded that future hypnotherapy systems are more likely to become hybrid human-AI solutions.