Current Issue
Volume 3, Issue 10 - 2026 (JPRIMS, Vol-3, Issue-10, October-2026)
Issue Details:
Volume 3 Issue 10 (JPRIMS, Vol-3, Issue-10, October-2026)Dr. Arpan Kumar Tripathi
Editor-in-Chief
Journal of Pharmaceutical Research and Integrated Medical Sciences
Articles in This Issue
Open AccessDevelopment, Optimization and Characterization of Amlexanox-Loaded Electrospun Nanofibers for Oral Mucosal Drug Delivery
Amlexanox-loaded electrospun nanofibers were investigated as a buccal drug-delivery system for local management of aphthous ulceration. Amlexanox was a pale-yellow crystalline, odourless, metallic-tasting powder and showed a practical melting point of 333.0 °C. UV spectrophotometric analysis in phosphate buffer pH 6.8 showed λmax at 244 nm. PVA, PVP K30 and PVP K90 were screened by preliminary electrospinning trials. Drug-loaded PVP K30 did not sustain Taylor-cone formation, whereas PVP K90 supported drug-loaded electrospinning; A29 and A30 showed prolonged Taylor-cone formation and drug entrapment of 73.57% and 76.84%, respectively. A two-factor, three-level optimization study evaluated PVP K90 concentration and tip-to-collector distance. For AF1–AF10, entrapment efficiency ranged from 70.4±2.3% to 81.6±2.0%, 12-h cumulative diffusion from 47.32% to 83.73%, and 24-h cumulative diffusion from 82.16% to 97.82%. The quadratic model for entrapment efficiency was significant (F=9.15, p=0.0260; R²=0.9196). AF11 showed 59.70% diffusion at 12 h and 91.58% at 24 h. The experimental dataset demonstrates the feasibility of PVP K90-based amlexanox nanofibers, while the coded-versus-actual optimization matrix and prospective stability study require reconciliation/completion before definitive optimized-product claims.
Contributors:
Open AccessCo-Solvency-Based Solid Dispersion of Ibuprofen Using Tamarind Seed Mucilage: A Sustainable Approach for Solubility and Bioavailability Enhancement
Ibuprofen is tough to dissolve in water and possess a limited bioavailability. To enhance dissolution, and stability, the study explores co-solvency-based solid dispersion method involving the application of tamarind seed mucilage as a natural polymer carrier. Drug:mucilage ratios of 1:0.5, 1:1, and 1:1.5, employing ethanol as a co-solvent under a solvent evaporation method. Equivalent physical mixtures were prepared for comparison. Along with FTIR and XRD studies endorsing ibuprofen's change to amorphous nature without chemical interaction with carrier, phytochemical tests established the presence of bioactive chemicals in the mucilage. Substantial progress was demonstrated in in vitro dissolving testing; the SD (3) 1:1.5 formulation had a dissolve efficiency of 91.6% and 99.8% drug release within 60 minutes. Particle size and zeta potential measurements indicated stable surface charges and nanoscale particles, particularly for SD (3). Compared to physical blends and pure ibuprofen, solid dispersions showed improved drug content and release effectiveness throughout the semiannual stability test under 40°C, 75% relative humidity. These results illustrate how tamarind seed mucilage can be utilized in co-solvency-based solid dispersions as an effective and environmentally friendly means of increasing solubility and therapeutic effectiveness of drugs with low aqueous solubility. This approach paves the way for improved drug delivery systems through offering a sustainable, scalable alternative and encouraging more research into natural carriers for drug formulations.
Contributors:
Open AccessBio-Inspired Drug Delivery Systems: Lessons from Nature for Pharmaceutical Innovation
Bio-inspired drug delivery systems are a relatively new area of development in the field of pharmaceutical science that applies the principles of nature to design a new system that will improve efficacy and safety in therapy. This is a review of recent developments in bio-inspired delivery platforms and, in particular, animal-based preclinical studies. Several biomimetic nanoparticles such as cell membrane-coated, exosome-mimetrics, virus-inspired, and biomimetic polymers are critically analyzed. The areas of focus of this review include the methodology of fabrication, targeting mechanism, biodistribution studies and therapeutic studies in animal models. The major findings are that bio-inspired systems are much better in terms of drug stability, circulation time, and tissue specificity as compared to systemic toxicity reduction. Even though such results are promising, they are subject to such difficulties as scalability, reproducibility, and translational reliability. This review presents the contemporary developments, limitations, and future research directions to clinical translation.