The current research was expected to standardize and analyze the pharmaceutical activity of a polyherbal syrup through the evaluation of physicochemical, phytochemical, and the pharmacological characteristics. The syrup was determined to be physicochemically stable with measure of dispatch in the pH, viscosity, total solids, refractive index and microbial load until phytochemical screening discovered the presence of alkaloids, flavonoids, tannins, saponins and phenolics. Pharmacological studies in albino Wistar rat animals indicated high dose-dependence of the anti-inflammatory and antioxidant effects on the subjects using large doses of syrup which produced effects similar to those of the standard reference drugs. The results prove the consistency, safety and the therapeutic potential of the syrup, which will allow using it in the future as a credible herbal preparation and as the basis of its further clinical confirmation and increase or reduce the dosage.