Aim and Objectives: This study aims to evaluate the role of physiotherapy in pain modulation and to provide mechanistic insights into non-pharmacological interventions that complement or substitute pharmacologic therapies. The objectives include reviewing underlying neurophysiological mechanisms, therapeutic techniques, and clinical evidence supporting physiotherapy in chronic pain management. Methodology:A literature review was conducted using PubMed, Scopus, and Web of Science, focusing on studies published between 2005 and 2025. Randomized controlled trials, systematic reviews, and mechanistic studies examining physiotherapy modalities—such as exercise therapy, manual therapy, transcutaneous electrical nerve stimulation (TENS), and therapeutic ultrasound—were analyzed. Results: Evidence suggests that physiotherapy alleviates pain through multiple mechanisms including modulation of nociceptive signaling, enhancement of endogenous opioid release, reduction of central sensitization, and improvement of musculoskeletal function. Interventions such as exercise therapy and TENS demonstrated significant reductions in pain intensity, improved mobility, and decreased reliance on pharmacological agents across diverse patient populations. Conclusion: Physiotherapy offers a safe, effective, and mechanistically validated non-pharmacological strategy for chronic pain management. By targeting neural, muscular, and psychosocial components of pain, physiotherapy serves as a vital adjunct or alternative to pharmacological treatments, promoting long-term functional recovery and enhanced quality of life.