The development of targeted medication delivery systems has created new ways to improve treatment outcomes, especially with the help of nanotechnology. The goal of this work was to create and describe pH-sensitive nanoparticles that would improve drug delivery by releasing the drug more in the intestines or other physiological settings and less in the stomach. We made nanoparticles in a lab by changing the ratio of polymer to drug using Eudragit® S100, PLGA, and chitosan. Characterization showed that larger polymer concentrations made the particles bigger (145–203 nm) and gave them more negative zeta potentials, which meant they were more stable. The efficiency of drug entrapment ranged from 61% to 84%, and it got better as the amount of polymer rose. SEM analysis indicated that the particles were spherical and evenly spread out. In vitro release assays showed that the drug's release depended on pH, with the least release at pH 1.2 and the most release between pH 6.8 and 7.4. ANOVA and Tukey HSD statistical tests showed that these results were strong. In general, the work shows that pH-sensitive nanoparticles could be good carriers for targeted oral medication administration.