The discovery of effective organometallic catalysts is instrumental in driving catalytic processes in numerous industrial processes. The present research examines the synthesis, characterization, and catalytic activity of new organometallic complexes, including palladium (II) acetate (Pd(OAc)₂), platinum (II) chloride (PtCl₂), and rhodium (III) chloride (RhCl₃), and their ligand-based analogues. The complexes were prepared and characterized through NMR, IR, and XRD spectroscopy to establish their purity and structure. Catalytic experiments for hydrogenation and cross-coupling reactions were carried out, and the data indicated that Pd(OAc)₂ (ligand present) showed the highest catalytic activity, with 95% conversion and 93% yield for hydrogenation and 88% conversion and 85% yield for cross-coupling. Statistical evaluation by ANOVA supported the importance of differences in catalytic performance, where the Pd(OAc)₂ complexes were better than the rest of the tested catalysts. This research reveals the improved catalytic activity of Pd(OAc)₂ (with ligand), giving important insights into future industrial catalysis applications. The results imply that optimization and further investigation into ligand changes could result in more efficient and selective catalysts for a vast array of reactions.