Poor aqueous solubility is a critical issue in drug development, with implications on bioavailability and therapeutic activity. This research involves formulation and testing of an oral suspension of a poorly water-soluble drug with the aim of improving solubility, stability, and dissolution rates. A total of 20 formulations (F1–F20) were prepared employing different levels of suspending agents, surfactants, and stabilizers. All the formulations were evaluated in quintuplicate (n = 100) for physicochemical properties, in vitro dissolution profiles, and stability at various storage conditions. Formulations F10 and F15 exhibited maximum drug release (97.5% and 95.3% at 120 minutes, respectively) and best stability for 30 days, with negligible pH change and sedimentation volume ratio. Statistical comparison employing ANOVA validated enhanced solubility and dissolution of the drug compared with non-optimized formulations (p